Radiology Library
Landmark Evidence
Landmark trials, diagnostic accuracy studies, registries and guidelines — each summarised with its key results, limitations and the practice it changed.
- DAWN: Thrombectomy 6–24 Hours After StrokeInterventional Radiology
DAWN established the benefit of mechanical thrombectomy 6–24 hours after last known well in highly selected patients with anterior-circulation large-vessel occlusion and clinical-core mismatch.
- SAMMPRIS (2011): Intracranial Stenting versus Aggressive Medical ManagementInterventional Radiology
SAMMPRIS compared aggressive medical management alone with Wingspan intracranial stenting plus the same medical therapy in patients with recently symptomatic severe intracranial atherosclerotic stenosis.
- ARUBA (2014): Medical Management versus Intervention for Unruptured Brain AVMsInterventional Radiology
ARUBA compared medical management alone with medical management plus interventional therapy for adults with unruptured brain arteriovenous malformations. It found a lower short-to-medium-term risk of death or symptomatic stroke with medical management.
- DEFUSE 3 (2018): Perfusion-Selected Thrombectomy at 6–16 HoursInterventional Radiology
DEFUSE 3 established the benefit of mechanical thrombectomy 6–16 hours after last known well in selected anterior-circulation large-vessel occlusion with a favourable perfusion-mismatch profile.
- ISAT (2002): Endovascular Coiling versus Neurosurgical Clipping for Ruptured Intracranial AneurysmsInterventional Radiology
Landmark randomised comparison of endovascular coiling and neurosurgical clipping for ruptured intracranial aneurysms judged suitable for either treatment.